FREM1 Overexpression Lysate

Nature

Native

Tag/Conjugate

Unconjugated

Molecular Weight

241.9 kDa

Alternative Names

FREM1,BNAR; C9orf143; C9orf145; C9orf154; FLJ25461; TILRRFREM1 Over-expression Lysate ProductFREM1

Format

Liquid

Concentration

Batch dependent - please inquire should you have specific requirements.

Buffer

25mM Tris-HCl pH7.6, 150mM NaCl, 1% NP-40, 1mM EDTA, 1xProteinase inhibitor cocktail mix, 1mM PMSF and 1mM Na3VO4

Preservative

None

Storage

Store at -80°C. Avoid freeze-thaw cycles.

Antigen Description

This gene encodes a basement membrane protein that may play a role in craniofacial and renal development. Mutations in this gene have been associated with bifid nose with or without anorectal and renal anomalies. Alternatively spliced transcript variants encoding different isoforms have been described. PubMed ID 19940113 describes one such variant that initiates transcription within a distinct, internal exon; the resulting shorter isoform (named Toll-like/interleukin-1 receptor regulator, TILRR) is suggested to be a co-receptor of the interleukin 1 receptor family and may regulate receptor function and Toll-like receptor/interleukin 1 receptor signal transduction, contributing to the control of inflammatory response activation.

Keywords

FREM1,BNAR; C9orf143; C9orf145; C9orf154; FLJ25461; TILRRFREM1 Over-expression Lysate ProductFREM1