Human FREM1 blocking peptide (CDBP1287)

Synthetic Human FREM1 blocking peptide for BL

Product Overview
Blocking peptide for anti-FREM1 antibody
Target
FREM1
Nature
Synthetic
Species Reactivity
Human
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not suitable for human or animal consumption.
Procedure
None
Format
Liquid
Concentration
200 μg/ml
Size
50 μg
Buffer
PBS containing 0.02% sodium azide
Preservative
0.02% Sodium Azide
Storage
Store at -20℃, stable for one year.
UniProt ID
Antigen Description
This gene encodes a basement membrane protein that may play a role in craniofacial and renal development. Mutations in this gene have been associated with bifid nose with or without anorectal and renal anomalies. Alternatively spliced transcript variants encoding different isoforms have been described. PubMed ID 19940113 describes one such variant that initiates transcription within a distinct, internal exon; the resulting shorter isoform (named Toll-like/interleukin-1 receptor regulator, TILRR) is suggested to be a co-receptor of the interleukin 1 receptor family and may regulate receptor function and Toll-like receptor/interleukin 1 receptor signal transduction, contributing to the control of inflammatory response activation.
Function
binding; metal ion binding; sugar binding;
Synonyms
FREM1; FRAS1 related extracellular matrix 1; C9orf154, chromosome 9 open reading frame 154; FRAS1-related extracellular matrix protein 1; C9orf143; C9orf145; DKFZp686M16108; FLJ25461; TILRR; extracellular matrix protein QBRICK; BNAR; MOTA; TRIGNO2; C9orf154;

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References


Beck, TF; Shchelochkov, OA; et al. Novel Frem1-Related Mouse Phenotypes and Evidence of Genetic Interactions with Gata4 and Slit3. PLOS ONE 8:-(2013).
Dalezios, Y; Papasozomenos, B; et al. Ultrastructural localization of Fras1 in the sublamina densa of embryonic epithelial basement membranes. ARCHIVES OF DERMATOLOGICAL RESEARCH 299:337-343(2007).

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