Multiplex assay ready: PBS only formulation, ready for custom conjugation.
Summary
Specifications
Antibody Isotype
IgG
Clone
9D5
Species Reactivity
D. melanogaster
Immunogen
Drosophila melanogaster Dopamine transporter
Conjugate
Unconjugated
Applications
Application Notes
Suitable for use in IF. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
General Notes
Recombinant monoclonal antibody to D. melanogaster DAT. Produced utilizing a recombinant platform technology. It can be used in IF.
Target
Alternative Names
dopamine transporter; DAT; SLC6A3; DAT1; PKDYS
Citations
Publication ()
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References
X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine.
Most antidepressants elicit their therapeutic benefits through selective blockade of Na(+)/Cl(-)-coupled neurotransmitter transporters. Here we report X-ray structures of the Drosophila melanogaster dopamine transporter in complexes with the polycyclic antidepressants nisoxetine or reboxetine. The inhibitors stabilize the transporter in an outward-open conformation by occupying the substrate-binding site. These structures explain how interactions between the binding pocket and substituents on the aromatic rings of antidepressants modulate drug-transporter selectivity.
COA
Publication 
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