Anti-CK-MB antibody
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Creative Diagnostics offer a wide range of antibodies and antigens to various cardiac markers for immunoassay development on various platforms. You can source all your assay needs from one location.
Creatine Kinase MB Isoenzyme (CK-MB) consists of two subunits with a MW of 82 kD. It is one of three isoforms containing either two M subunits (CK-MM), two B subunits (CK-BB) or one of each M and B subunit (CK-MB).
CKMB levels increase with myocardial damage. Extreme elevations of CKMB can also be associated with skeletal muscle cell turnover as in polymyositis and to a lesser degree in rhabdomyolysis.
Although CK-MB elevated serum levels are highly specific for detecting heart damage, it has largely been replaced by Troponin assays. However, recently, there have been improvements to the test that involve measuring the ratio of the CK-MB1 and CK-MB2 isoforms.
Copeptin, a 39-amino acid glycopeptide that comprises the C-terminal part of the AVP precursor (CT-proAVP), was found to be a stable and sensitive surrogate marker for AVP release, analogous to C-peptide for insulin. Copeptin measurement has been shown to be useful in various clinical indications, such as acute myocardial infarction, heart failure, hyponatremia, and sepsis.
Lipoprotein-associated phospholipase A2 (Lp-PLA2) also known as platelet-activating factor acetylhydrolase (PAF-AH) is a phospholipase A2 enzyme that in humans is encoded by the PLA2G7 gene. Lp-PLA2 is a 45-kDa protein of 441 amino acids.
Lp-PLA2 has been firmly implicated in release of lysophospholipid and oxidized fatty acids in lipoprotein(a) (Lp(a)) particles. This finding may help to explain the increased risk for CHD in subjects with elevated levels of serum Lp(a).
PAPPA (pregnancy-associated plasma protein A) also know as Pappalysin-1, is a secreted protease whose main substrate is insulin-like growth factor binding proteins. Pappalysin-1 is also used in screening tests for Down syndrome.
S100 calcium-binding protein B (S100B) is a protein of the S-100 protein family.S100B has emerged as a candidate peripheral biomarker of blood–brain barrier (BBB) permeability and CNS injury. Elevated S100B levels accurately reflect the presence of neuropathological conditions including traumatic head injury or neurodegenerative diseases.
ST2 is a protein biomarker of cardiac stress encoded by the IL1RL1 gene and has 2 isoforms that are directly implicated in progression of cardiac disease: soluble ST2 (sST2) and a transmembrane-bound form, ST2 ligand (ST2L). High concentrations of sST2 result in cellular death, tissue fibrosis, reduced cardiac function, and an increase in the rate of disease progression.
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