Anti-SKP1 Polyclonal Antibody (CABT-L2183) Knockout Validated

Rabbit Anti-Human SKP1 (Met1~Lys163) Polyclonal Antibody for WB

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human, Rat, Pig
Immunogen
Recombinant fragment corresponding to human SKP1 (Met1~Lys163)
Conjugate
Unconjugated

Applications


Application Notes
Recommended dilution: WB: 0.5-2 ug/ml
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Data Examples


Knockout Varification: Lane 1: Wild-type Hela cell lysate. Lane 2: SKP1 knockout Hela cell lysate. Predicted MW: 18, 19kd, Observed MW: 20kd
Figure. Western Blot. Sample. Lane1: Human 293T Cells; Lane2: Porcine Brain Tissue; Lane3: Rat Brain Tissue.

Target


Alternative Names
SKP1A; EMC19; OCP-II; OCP2; TCEB1L; p19A
Entrez Gene ID
UniProt ID

Product Background


Pathway
AMER1 mutants destabilize the destruction complex; APC truncation mutants are not K63 polyubiquitinated; APC truncation mutants have impaired AXIN binding; APC/C-mediated degradation of cell cycle proteins; AXIN missense mutants destabilize the destruction complex; AXIN mutants destabilize the destruction complex, activating WNT signaling; Activation of NF-kappaB in B cells; Adaptive Immune System;

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Surjit, M; Varshney, B; et al. The ORF2 glycoprotein of hepatitis E virus inhibits cellular NF-kappa B activity by blocking ubiquitination mediated proteasomal degradation of I kappa B alpha in human hepatoma cells. BMC BIOCHEMISTRY 13:-(2012).
Ramakrishnan, R; Liu, HB; et al. Identification of novel CDK9 and Cyclin T1-associated protein complexes (CCAPs) whose siRNA depletion enhances HIV-1 Tat function. RETROVIROLOGY 9:-(2012).

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