Anti-SKP1 (full length) polyclonal antibody

Species Reactivity

Human

Immunogen

SKP1A (AAH25673, 1 a.a. ~ 160 a.a) full-length recombinant protein with GST tag. The sequence is MPSIKLQSFDGEIFEVDVEIAKQSVTIKTMLEDLGMDDEGDDDPVPLPNVNAAILKKVIQ WCTHHKDDPPPPEDDENKEKRTDDIPVWDQEFLKVDQGTLFELILAANYLDIKGLLDVTC KTVANMIKGKTPEEIRKTFNIKNDFTEEEEAQVGSTQFCL

Conjugate

Alternative Names

SKP1; S-phase kinase-associated protein 1; OCP2; p19A; EMC19; SKP1A; OCP-II; TCEB1L; SIII; OCP-2; p19skp1; organ of Corti protein 2; organ of Corti protein II; cyclin A/CDK2-associated p19; cyclin A/CDK2-associated protein p19; cyclin-A/CDK2-associated pr

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.

Pathway

APC/C-mediated degradation of cell cycle proteins; Adaptive Immune System; Proteasome degradation; Cell Cycle