Anti-PSMa5 Polyclonal Antibody (CABT-L2192) Knockout Validated

Rabbit Anti-Human PSMa5 (Met1~Ile241) Polyclonal Antibody for WB

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Recombinant fragment corresponding to human PSMA5 (Met1~Ile241)
Conjugate
Unconjugated

Applications


Application Notes
Recommended dilution: WB: 0.5-2 ug/ml
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Data Examples


Knockout Varification: Lane 1: Wild-type Hela cell lysate. Lane 2: PSMa5 knockout Hela cell lysate. Predicted MW: 26, 20kd, Observed MW: 27kd
Figure. Western Blot. Sample. Lane1: Human Lung Tissue; Lane2: Human Hela Cells.

Target


Alternative Names
PSC5; Macropain zeta chain; Multicatalytic endopeptidase complex zeta chain; Proteasome zeta chain
Entrez Gene ID
UniProt ID

Product Background


Pathway
AMER1 mutants destabilize the destruction complex; APC truncation mutants are not K63 polyubiquitinated; APC truncation mutants have impaired AXIN binding; APC/C-mediated degradation of cell cycle proteins; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdc20 mediated degradation of mitotic proteins; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell c

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Livinskaya, VA; Ivanov, VA; et al. Polyclonal Antibodies Against Human Proteasome Subunits PSMA3, PSMA5, and PSMB5. HYBRIDOMA 31:272-278(2012).
Hong, Y; Han, HX; et al. Schistosoma japonicum: Cloning, expression and characterization of a gene encoding the alpha 5-subunit of the proteasome. EXPERIMENTAL PARASITOLOGY 126:517-525(2010).

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