The proteasome is a multicatalytic proteinase complex witha highly ordered ring-shaped 20S core structure. The core structureis composed of 4 rings of 28 non-identical subunits; 2 rings arecomposed of 7 alpha subunits and 2 rings are composed of 7 betasubunits. Proteasomes are distributed throughout eukaryotic cellsat a high concentration and cleave peptides in anATP/ubiquitin-dependent process in a non-lysosomal pathway. Anessential function of a modified proteasome, the immunoproteasome,is the processing of class I MHC peptides. This gene encodes amember of the peptidase T1A family, that is a 20S core alphasubunit.
Pathway
APC/C-mediated degradation of cell cycle proteins; APC/C:Cdc2 mediated degradation of Securin; APC/C:Cdc2 mediated degradation of mitotic proteins; APC/C:Cdh1 mediated degradation of Cdc2 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Activation of APC/C and APC/C:Cdc2 mediated degradation of mitotic proteins; Activation of NF-kappaB in B Cells; Adaptive Immune System; Antigen processing-Cross presentation.
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