Anti-MASP1 Polyclonal Antibody (CABT-L2079) Knockout Validated

Rabbit Anti-Human MASP1 (His25~Arg453) Polyclonal Antibody for WB

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fragment corresponding to human MASP1 (His25~Arg453)
Conjugate
Unconjugated

Applications


Application Notes
Recommended dilution: WB: 0.5-2 ug/ml
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Data Examples


Knockout Varification: Lane 1: Wild-type Hela cell lysate. Lane 2: MASP1 knockout Hela cell lysate. Predicted MW: 80, 82kDa, Observed MW: 90kDa
Figure. Western Blot. Sample. Lane1: Rat Liver Tissue; Lane2: Human Hela Tissue.

Target


Alternative Names
CRARF; PRSS5; Mannan-Binding Lectin Serine Peptidase 1; Ra-reactive factor serine protease p100; Complement-activating component of Ra-reactive factor; Serine protease 5
Entrez Gene ID
UniProt ID

Product Background


Pathway
Binding and Uptake of Ligands by Scavenger Receptors; Complement Activation, Classical Pathway; Complement and Coagulation Cascades; Complement and coagulation cascades; Complement cascade; Creation of C4 and C2 activators; Ficolins bind to repetitive carbohydrate structures on the target cell surface; Immune System;

Citations


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References


Skjoedt, MO; Palarasah, Y; et al. MBL-associated serine protease-3 circulates in high serum concentrations predominantly in complex with Ficolin-3 and regulates Ficolin-3 mediated complement activation. IMMUNOBIOLOGY 215:921-931(2010).
Degn, SE; Jensen, L; et al. Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system. JOURNAL OF IMMUNOLOGICAL METHODS 361:37-50(2010).

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