Anti-MASP1 monoclonal antibody, clone NN0208-5G20

Antibody Isotype

IgG2

Clone

NN0208-5G20

Species Reactivity

Human

Immunogen

Recombinant fragment (Human)

Conjugate

Application Notes

WB: 1/500 - 1/1000.

Alternative Names

MASP1; mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor); CRARF,mannan binding lectin serine protease 1 (C4/C2 activating component of Ra reactive factor) , PRSS5; mannan-binding lectin serine protease 1; MASP; Co

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.

Pathway

Complement Activation, Classical Pathway, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Complement cascade, organism-specific biosystem; Creation of C4 and C2 activators, organism-specific biosystem; Immune System, organism-specific biosystem; Initial triggering of complement, organism-specific biosystem; Innate Immune System.