E. coli-derived recombinant mouse IL?20 Leu25-Leu176
Conjugate
Biotin
Applications
Application Notes
Western Blot: 0.1 ug/mL ELISA Detection: 0.1-0.4 ug/mL
Product Background
Antigen Description
Mouse Interleukin 20 (IL20) was identified by searching sequence databases for translated sequences with a signal sequence and amphipathic helices found in helical cytokines. Based on the human molecule, mouse IL20 was discovered in a skin library. Mouse IL20 is synthesized as a 176 amino acid (aa) precursor that contains a 24 aa signal sequence and a 152 aa mature segment. There are no Nlinked glycosylation sites and it is doubtful that the native molecule is glycosylated. Although IL20 is a distant member of the IL-10 family, it functions as a monomer. IL20 shares less than 40% aa sequence identity with other IL10 family members. Mouse and human IL20 are 77% aa identical in the mature segment. IL20 production has been found in skin and trachea. In particular, activated keratinocytes and,possibly, monocytes are reported to express IL20. There are two heterodimeric receptor complexes for IL20. The first complex is composed of IL20 Rα and IL-20 Rβ. The second complex is composed of IL22 R and IL-20 Rβ. Whereas the IL-22 R/IL-20 Rβ complex is shared with IL24/mda7, the IL-20 Rα/IL-20 Rβcomplex is shared with both IL19 and IL24. Little is known about the function of IL20. It is reported to induce the proliferation of multipotential hematopoietic progenitor cells, direct the differentiation and expansion of keratinocytes, and promote the release of proinflammatory mediators in keratinocytes and other IL20 receptor expressing cells (1-6).
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