Anti-IL20 monoclonal antibody, clone 287008

Antibody Isotype

IgG2a

Clone

287008

Species Reactivity

Mouse

Immunogen

E. coli-derived recombinant mouse IL-20. Leu25-Leu176 Accession Number Q9JKV9.1

Conjugate

Application Notes

ELISA Capture: 2-8 μg/mL; ELISA Detection: 0.1-0.4 μg/mL
We recommend the following for sandwich ELISA (Capture - Detection):
DCABY-4081 - DPABY-698

Alternative Names

IL20; interleukin 20; Zcyto10; interleukin-20; IL-20; cytokine Zcyto10; four helix bundle cytokine 10; four alpha helix cytokine ZCYTO10;

Entrez Gene ID

UniProt ID

Antigen Description

Mature human and mouse IL-20 is a 152 amino acid protein that is not likely glycosylated. Although IL-20 is a distant member of the IL-10 family, it functions as a monomer. IL-20 binds two heterodimeric receptor complexes, IL-20 R alpha/IL-20 R beta and IL-22 R/IL-20 R beta. IL-20 is reported to induce the proliferation of multipotential hematopoietic progenitor cells, direct the differentiation and expansion of keratinocytes, and promote the release of proinflammatory mediators in keratinocytes and other IL-20 receptor-expressing cells.

Pathway

Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;