This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Mar 2010]
Function
zinc ion binding
Synonyms
ZMIZ1; zinc finger, MIZ-type containing 1; MIZ; RAI17; ZIMP10; hZIMP10; TRAFIP10; zinc finger MIZ domain-containing protein 1; RP11-519K18.1; FLJ00092 protein; retinoic acid induced 17; zinc finger-containing, Miz1, PIAS-like protein on chromosome 10
Citations
Publication ()
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