Anti-ZMIZ1 polyclonal antibody (DPABH-03051)

Rabbit anti-Human ZMIZ1 (N-terminal) polyclonal antibody for ICC/IF, WB, ICC

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Synthetic peptide corresponding to 15 amino acids near the N terminal of Human Zinc finger MIZ domain-containing protein 1
Conjugate
Unconjugated

Applications


Application Notes
ICC/IF: 20 μg/ml. WB: 0.5 - 1 μg/ml. ICC: 10 μg/ml.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
ZMIZ1; zinc finger, MIZ-type containing 1; MIZ; RAI17; ZIMP10; hZIMP10
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ZMIZ1 (Zinc Finger MIZ-Type Containing 1) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway and Androgen receptor signaling pathway. An important paralog of this gene is PIAS2. This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia.
Antigen Description
Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation. Zinc finger MIZ domain-containing protein 1 is a protein that in humans is encoded by the ZMIZ1 gene. 0The function about ZMIZ1 antigen include zinc ion binding.
Pathway
Androgen receptor signaling pathway; Integrated Breast Cancer Pathway.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Senapati, S; Gutierrez-Achury, J; et al. Evaluation of European coeliac disease risk variants in a north Indian population. EUROPEAN JOURNAL OF HUMAN GENETICS 23:530-535(2015).

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