ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.[supplied by OMIM, Mar 2008]
Function
endonuclease activity; metal ion binding; protein binding
Synonyms
ZC3H12A; zinc finger CCCH-type containing 12A; MCPIP; MCPIP1; dJ423B22.1; ribonuclease ZC3H12A; MCP induced protein 1; MCP-induced protein 1; MCP-1 treatment-induced protein; zinc finger CCCH domain-containing protein 12A
Citations
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Koga, T; Yamasaki, S; et al. Post-transcriptional regulation of IL-6 production by Zc3h12a in fibroblast-like synovial cells. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 29:906-912(2011).
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COA
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