Anti-UBE2E1 (aa 72-121) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to a region within internal amino acids 72 - 121 (KGDNIYEWRS TILGPPGSVY EGGVFFLDIT FTPEYPFKPP KVTFRTRIYH) of Human UBCH6/UBE2E1.

Conjugate

Application Notes

WB: 1μg/ml

Alternative Names

UBE2E1; ubiquitin-conjugating enzyme E2E 1; ubiquitin conjugating enzyme E2E 1 (homologous to yeast UBC4/5) , ubiquitin conjugating enzyme E2E 1 (UBC4/5 homolog, yeast); ubiquitin-conjugating enzyme E2 E1; UbcH6; UB2E1_HUMAN; UbcH6; UBE2E1; Ubiquitin carrier protein E1; Ubiquitin-conjugating enzyme E2 E1; Ubiquitin-protein ligase E1; OTTHUMP00000161049; OTTHUMP00000161050; OTTHUMP00000208307; OTTHUMP00000208308; OTTHUMP00000208309; ubiquitin-protein ligase E1; ubiquitin carrier protein E1; ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast); ubiquitin-conjugating enzyme E2E 1 (homologous to yeast UBC4/5); UBCH6;

Entrez Gene ID

UniProt ID

Antigen Description

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Pathway

APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Cyclin B, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; Activation of APC/C and APC/C:Cdc20 mediated degradat