Specifications
Immunogen
A synthetic peptide of human UBE2E1 is used for rabbit immunization.
Target
Alternative Names
UBE2E1; ubiquitin-conjugating enzyme E2E 1; ubiquitin conjugating enzyme E2E 1 (homologous to yeast UBC4/5) , ubiquitin conjugating enzyme E2E 1 (UBC4/5 homolog, yeast); ubiquitin-conjugating enzyme E2 E1; UbcH6; ubiquitin-protein ligase E1; ubiquitin car
Product Background
Antigen Description
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Pathway
APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc2 mediated degradation of Cyclin B, organism-specific biosystem; APC/C:Cdc2 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc2 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc2 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; Activation of APC/C and APC/C:Cdc2 mediated degradat.
Citations
Publication ()
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COA
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