This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis. [provided by RefSeq, Jul 2008]
Function
metal ion binding; protein binding; receptor signaling protein activity; zinc ion binding;
Synonyms
TRAIP; TRAF interacting protein; TRAF-interacting protein; ring finger protein 206; RNF206; TRIP;
Citations
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