This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
Function
3'-5' exonuclease activity; 3'-5' exonuclease activity; 3'-5'-exodeoxyribonuclease activity; MutLalpha complex binding; MutSalpha complex binding; adenyl deoxyribonucleotide binding; double-stranded DNA binding; exodeoxyribonuclease III activity; metal ion binding; metal ion binding; protein homodimerization activity; protein homodimerization activity; single-stranded DNA binding
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