Anti-TREX1 (aa 182-369) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant fragment, corresponding to a region within amino acids 182-369 of Human TREX1 (UniProt ID: Q9NSU2).

Conjugate

Application Notes

WB: 1/500 - 1/3000.

Alternative Names

TREX1; three prime repair exonuclease 1; AGS1, Aicardi Goutieres syndrome 1; DRN3; DNase III; 3 repair exonuclease 1; 3-5 exonuclease TREX1; CRV; AGS1; HERNS; DKFZp434J0310;

Entrez Gene ID

UniProt ID

Antigen Description

TREX1 is the major 3->5 DNA exonuclease in human cells. The protein is a non processive exonuclease that may serve a proofreading function for a human DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3 ends of nicked DNA during granzyme A mediated cell death. Mutations in this gene result in Aicardi Goutieres syndrome, chilblain lupus, and Cree encephalitis. Multiple transcript variants encoding different isoforms have been found for this gene.

Pathway

Cytosolic DNA-sensing pathway;