TARBP1 blocking peptide

Nature

Synthetic

Tag/Conjugate

Unconjugated

Format

Liquid

Concentration

200 μg/mL

Preservative

None

Storage

-20°C

Gene ID

6894

UniProt ID

Q13395

Antigen Description

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. This element forms a stable stem-loop structure and can be bound by either the protein encoded by this gene or by RNA polymerase II. This protein may act to disengage RNA polymerase II from TAR during transcriptional elongation. Alternatively spliced transcripts of this gene may exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]

Function

RNA binding; RNA methyltransferase activity

Synonyms

TARBP1; TAR (HIV-1) RNA binding protein 1; TRM3; TRP185; TRP-185; probable methyltransferase TARBP1; TAR RNA-binding protein 1; TAR RNA loop binding protein; TAR (HIV) RNA binding protein 1; TAR (HIV) RNA-binding protein 1; tRNA methyltransferase 3 homolog; TAR RNA-binding protein of 185 kDa