This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway. [provided by RefSeq, Mar 2012]
Function
ligase activity; metal ion binding; ubiquitin-protein ligase activity; zinc ion binding;
Synonyms
RNF125; ring finger protein 125, E3 ubiquitin protein ligase; ring finger protein 125; E3 ubiquitin-protein ligase RNF125; FLJ20456; T-cell RING activation protein 1; T-cell ring protein identified in activation screen; TRAC1; TRAC-1; MGC21737;
Citations
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