Anti-RNF125 (aa 143-231) polyclonal antibody

Species Reactivity

Human

Immunogen

RNF125 (NP_060301, 143 a.a. ~ 231 a.a) partial recombinant protein with GST tag. The sequence is FCQRELYEDSLLDHCITHHRSERRPVFCPLCRLIPDENPSSFSGSLIRHLQVSHTLFYDD FIDFNIIEEALIRRVLDRSLLEYVNHSNT

Conjugate

Alternative Names

RNF125; ring finger protein 125, E3 ubiquitin protein ligase; TRAC1; TRAC-1; E3 ubiquitin-protein ligase RNF125; T-cell RING activation protein 1; T-cell ring protein identified in activation screen;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway.

Pathway

Immune System; Negative regulators of RIG-I/MDA5 signaling; RIG-I-like receptor signaling pathway.