Rabbit Anti-Human TMPRSS6 (a.a. 76-375) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse; Rat

Immunogen

Recombinant human TMPRSS6 protein; Source: E. coli derived, PGEX-4T; Tag: GST; Domain: 76-375 aa of BC039082

Conjugate

Application Notes

WB: 1:500-1:1000

General Notes

This product (Catalog No. CABT-BL3630) is a rabbit-derived polyclonal antibody raised against human TMPRSS6, targeting the amino acid region 76–375 of the protein. This antibody exhibits cross-reactivity with Human TMPRSS6 from mouse and rat. It has been affinity purified by Protein A. The type II transmembrane serine protease TMPRSS6 (also known as matriptase-2) controls iron homeostasis through its negative regulation of expression of hepcidin, a key hormone involved in iron metabolism. Upstream of the hepcidin-regulated signaling pathway, TMPRSS6 cleaves its target substrate hemojuvelin (HJV) at the plasma membrane(PMID:21724843).It Belongs to the peptidase S1 family.Defects in TMPRSS6 are the cause of iron-refractory iron deficiency anemia (IRIDA).It has 4 isoforms produced by alternative splicing.
CABT-BL3630 is suitable for use in Western blot (WB) (1:500–1:1,000) application.
CABT-BL3630 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

IRIDA; Matriptase 2; TMPRSS6

Entrez Gene ID

UniProt ID