This gene is a member of an orphan homeobox-containing transcription factor family. Studies of the mouse ortholog have shown that the encoded protein is crucial for the development of the enteric nervous system; in humans, loss-of-function may play a role in tumorigenesis of gastrointestinal stromal tumors. [provided by RefSeq, May 2010]
Function
molecular_function; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity
Synonyms
TLX2; T-cell leukemia homeobox 2; NCX; HOX11L1; T-cell leukemia homeobox protein 2; homeo box 11-like 1; homeobox protein Hox-11L1; neural crest homeobox protein
Citations
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Inagaki, K; Otsuka, F; et al. Involvement of bone morphogenetic protein-6 in differential regulation of aldosterone production by angiotensin II and potassium in human adrenocortical cells. ENDOCRINOLOGY 147:2681-2689(2006).
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COA
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