Product Overview
Blocking/Immunizing peptide for anti-TIAL1 and TIA antibody
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]
Function
RNA binding; nucleic acid binding; nucleotide binding;
Synonyms
TIAL1; TIA1 cytotoxic granule-associated RNA binding protein-like 1; TIA1 cytotoxic granule associated RNA binding protein like 1; nucleolysin TIAR; TIAR; T-cluster binding protein; TIA-1-related nucleolysin; aging-associated gene 7 protein; TCBP; MGC33401;
Citations
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Yeowell, HN; Walker, LC; et al. TIA Nuclear Proteins Regulate the Alternate Splicing of Lysyl Hydroxylase 2. JOURNAL OF INVESTIGATIVE DERMATOLOGY 129:1402-1411(2009).
Izquierdo, JM; Alcalde, J; et al. Knockdown of T-cell intracellular antigens triggers cell proliferation, invasion and tumour growth. BIOCHEMICAL JOURNAL 435:337-344(2011).