Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq, Jul 2008]
Function
palmitoyl-CoA hydrolase activity
Synonyms
THEM4; thioesterase superfamily member 4; CTMP; acyl-coenzyme A thioesterase THEM4; acyl-CoA thioesterase THEM4; C-terminal modulator protein; carboxyl-terminal modulator protein
Citations
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