Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq, Jul 2008]
Pathway
Activation of PKB; Adaptive Immune System; CD28 co-stimulation; CD28 dependent PI3K/Akt signaling; Costimulation by the CD28 family; DAP12 interactions; DAP12 signaling; Disease
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