Human PTPN2 peptide

Specificity

Isoform PTPA is probably the major isoform. Isoform PTPB is expressed in T-cells and in placenta.

Nature

Synthetic

Tag/Conjugate

Unconjugated

SequenceSimilarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.Contains 1 tyrosine-protein phosphatase domain.

Format

Liquid

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Entrez Gene ID

Antigen Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]

Function

integrin binding; protein binding; protein kinase binding; protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; syntaxin binding;

Synonyms

PTPN2; protein tyrosine phosphatase, non-receptor type 2; PTN2; PTPT; TCPTP; TC-PTP; TCELLPTP; tyrosine-protein phosphatase non-receptor type 2; T-cell protein tyrosine phosphatase;