Anti-PTPN2 (full length) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat; Human

Immunogen

Recombinant full length protein corresponding to Human TCPTP aa 1-353. (Isoform 3)Sequence: MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRD VSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLM VWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDV KSYYTVHLLQ

Conjugate

Application Notes

WB: 1/500 - 1/2000; IHC-P: 1/50 - 1/200;

Alternative Names

PTPN2; protein tyrosine phosphatase, non-receptor type 2; PTN2; PTPT; TCPTP; TC-PTP; TCELLPTP; tyrosine-protein phosphatase non-receptor type 2; T-cell protein tyrosine phosphatase;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.

Pathway

Cytokine Signaling in Immune system; Interferon Signaling; Regulation of IFNG signaling;