Anti-TAF1 monoclonal antibody, clone 2H0

Antibody Isotype

IgG

Clone

2H0

Species Reactivity

Human

Immunogen

TAF1 (NP_004597, 1784 aa ~ 1893 aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

EC 2.7.11.1; DYT3; BA2R; dystonia 3 (with Parkinsonism); CCG1; TATA box binding protein (TBP)-associated factor, RNA polymerase II, A, 250kD; OF; KAT4; P250; NSCL2; XDP; Cell cycle gene 1 protein; cell cycle, G1 phase defect; Transcription initiation factor TFIID 250 kDa subunit; complementation of cell cycle block, G1-to-S; CCGS; transcription factor TFIID p250 polypeptide; transcription initiation factor TFIID subunit 1; TBP-associated factor 250 kDa; EC 2.7.11; TAF2A; N-TAF1; TAFII250; DYT3/TAF1; TAFII-250; TAF(II)250; OTTHUMP00000024334; OTTHUMP00000024335

Entrez Gene ID

UniProt ID

Antigen Description

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. This gene is part of a complex transcriptional unit (TAF1/DYT3), wherein some products share exons with TAF1 as well as additional exons downstream.Mouse monoclonal antibody raised against a partial recombinant TAF1.

Pathway

Basal transcription factors, organism-specific biosystem; Basal transcription factors, conserved biosystem; Formation and Maturation of mRNA Transcript, organism-specific biosystem; Gene Expression, organism-specific biosystem; HIV Infection, organism-specific biosystem; HIV Life Cycle, organism-specific biosystem