Specifications
Species Reactivity
Mouse; Rat; Human
Immunogen
Synthetic peptide corresponding to Human KAT4/ TBP Associated Factor 1.Database link: P21675
Applications
Application Notes
WB: 1/1000 - 1/5000;
Target
Alternative Names
TAF1; TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa; BA2R, CCG1, CCGS, dystonia 3 (with Parkinsonism) , DYT3, TAF2A, TATA box binding protein (TBP) associated factor, RNA polymerase II, A, 250kD; transcription initiati
Product Background
Antigen Description
Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on Thr-55 which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle.
Pathway
Basal transcription factors, organism-specific biosystem; Basal transcription factors, conserved biosystem; Disease, organism-specific biosystem; Gene Expression, organism-specific biosystem; HIV Infection, organism-specific biosystem; HIV Life Cycle, organism-specific biosystem; HIV-1 Transcription Initiation, organism-specific biosystem;
Citations
Publication ()
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COA
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