RHA™ anti-Soybean agglutinin monoclonal antibody, clone SBA

MCM-41 and SBA-15 have many applications in chemical processes. However, the high cost of producing these materials limits their applications to a large-scale. To reduce production costs and promote recycling of industrial waste, this study presents methodologies for the synthesis of MCM-41 and SBA-15 using glass powder, rice husk ash and sugarcane bagasse ash. The methodologies consist of dissolving the raw materials in a sodium hydroxide solution under mild reaction conditions and subsequently using it as reactive silica source, to synthesize the MCM-41 and SBA-15 hybrid silicas. The materials were synthesized in two steps. The first step of SBA-15 occurred at 35 degrees C for 24 h and the hydrothermal synthesis occurred at 100 degrees C for 48 h. For MCM-41, these steps occurred at 28 degrees C for 2 h and 150 degrees C for 96 h, respectively. The samples were characterized using X-ray Diffraction (XRD), Energy-dispersive X-ray Fluorescence (ED-XRF), Scanning Electron Microscopy (SEM), and Fourier Transform Infrared Spectroscopy (FTIR). The results showed that the basic treatment of the raw materials was effective in increasing the reactivity of the alternative silica sources and eliminating the negative effects of impurities. Moreover, the results showed that the syntheses produced highly-ordered materials, free of contaminants.

The main objective of this study is to develop readily accessible and recyclable solid catalysts for enantioselective reactions. To achieve this, magnetic MCM-41 and non-magnetic SBA-15 mesoporous supports were prepared, then mesoporous silica supported chiral urea-amine bifunctional catalysts were synthesized by grafting of chiral urea-amine ligand onto SBA-15 and magnetic MCM-41. The magnetic and non-magnetic supports and so-prepared solid catalysts were characterized by using different methods such as N(2)sorption measurements, Fourier transform infrared spectroscopy (FT-IR), field emission scanning electron microscope-energy dispersive X-ray analysis (FESEM-EDX), X-ray diffraction (XRD), and thermogravimetric analysis (TGA). Results showed that (1R, 2R) or (1S, 2S)-1,2-diphenylethane-1,2-diamine was successively immobilized onto magnetic MCM-41 and SBA-15 pores. The heterogeneous chiral solid catalysts and their homogenous counterparts exhibited high activities both enantioselective transfer hydrogenation reaction (up to 99% conversion and 65%ee) and enantioselective Michael reaction (up to 98% conversion and 26%ee). Moreover, the SBA-15 supported solid catalysts were separated from the reaction mixture by simple filtration, whereas the magnetic MCM-41 supported solid catalysts were separated by simple magnetic decantation and reused in three consecutive catalytic experiments.