Product Overview
Blocking/Immunizing peptide for anti-Smooth muscle alpha-actin antibody
Target
Smooth muscle alpha-actin
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
Synonyms
ACTA2; actin, alpha 2, smooth muscle, aorta; AAT6; ACTSA; MYMY5; actin, aortic smooth muscle; alpha-cardiac actin; cell growth-inhibiting gene 46 protein;
Citations
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Milewicz, DM; Guo, DC; et al. Genetic basis of thoracic aortic aneurysms and dissections: Focus on smooth muscle cell contractile dysfunction. ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS 9:283-302(2008).
Leimgruber, C; Quintar, AA; et al. Dedifferentiation of Prostate Smooth Muscle Cells in Response to Bacterial LPS. PROSTATE 71:1097-1107(2011).