Tag/Conjugate
Unconjugated
Purity
> 95 % by SDS-PAGE.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.
Reconstitution
ACTA2 peptide is supplied as 1mg of dried peptide. When the peptide is reconstituted in 1 mL strile water, the concentration will be 1 mg/mL.
Introduction
The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
Synonyms
ACTA2; actin, alpha 2, smooth muscle, aorta; AAT6; ACTSA; MYMY5; actin, aortic smooth muscle; alpha-cardiac actin; cell growth-inhibiting gene 46 protein;
Citations
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Amans, MR; Stout, C; et al. Cerebral arteriopathy associated with Arg179His ACTA2 mutation. JOURNAL OF NEUROINTERVENTIONAL SURGERY 6:E46-+(2014).
Lee, HW; Park, YM; et al. Alpha-Smooth Muscle Actin (ACTA2) Is Required for Metastatic Potential of Human Lung Adenocarcinoma. CLINICAL CANCER RESEARCH 19:5879-5889(2013).