This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008]
Function
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; chromatin binding; metal ion binding; sequence-specific DNA binding
Synonyms
SNAI2; snail family zinc finger 2; SLUG; WS2D; SLUGH1; SNAIL2; zinc finger protein SNAI2; snail homolog 2; protein snail homolog 2; neural crest transcription factor SLUG; slug (chicken homolog), zinc finger protein
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