SNAI2 (NP_003059, 97 a.a. ~ 169 a.a) partial recombinant protein with GST tag. The sequence is KDHSGSESPISDEEERLQSKLSDPHAIEAEKFQCNLCNKTYSTFSGLAKHKQLHCDAQSR KSFSCKYCDKEYV
This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects.
Pathway
Adherens junction; Direct p53 effectors; Hippo signaling pathway; Regulation of Wnt-mediated beta catenin signaling and target gene transcription
Citations
Publication ()
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