Tag/Conjugate
Unconjugated
Antigen Description
Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]).[supplied by OMIM, Mar 2008]
Synonyms
SLITRK5; SLIT and NTRK-like family, member 5; LRRC11; bA364G4.2; SLIT and NTRK-like protein 5; slit and trk like gene 5; leucine rich repeat containing 11; leucine-rich repeat-containing protein 11
Citations
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Yang, XW; Lu, XH; et al. Molecular and cellular basis of obsessive-compulsive disorder-like behaviors: emerging view from mouse models. CURRENT OPINION IN NEUROLOGY 24:114-118(2011).
Shmelkov, SV; Hormigo, A; et al. Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice. NATURE MEDICINE 16:598-U135(2010).
COA
Certificate of Analysis
