This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Function
ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity;
Sonnen, KF; Schermelleh, L; et al. 3D-structured illumination microscopy provides novel insight into architecture of human centrosomes. BIOLOGY OPEN 1:965-976(2012).
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