Mouse STAT5B blocking peptide

Product Overview

STAT5b ( C - term ) peptide ( mouse )

Target

STAT5b

Nature

Synthetic

Tag/Conjugate

Unconjugated

Format

Liquid

Concentration

0.2 mg/ml

Buffer

PBS with 100ug BSA 0.1% sodium azide

Preservative

0.1% Sodium Azide

Storage

Keep as concentrated solution, aliquot and store at 4°C.

Entrez Gene ID

Antigen Description

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]

Function

DNA binding; DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; calcium ion binding; double-stranded DNA binding; glucocorticoid receptor binding; protein binding; sequence-specific DNA binding; sequence-specific DNA binding trans

Synonyms

STAT5B; signal transducer and activator of transcription 5B; mammary gland factor STAT5B;