Anti-STAT5B (aa 678-787) polyclonal antibody

Species Reactivity

Human

Immunogen

STAT5B (NP_036580, 678 a.a. ~ 787 a.a) partial recombinant protein with GST tag. The sequence is VYSKYYTPVPCESATAKAVDGYVKPQIKQVVPEFVNASADAGGGSATYMDQAPSPAVCPQ AHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQWIPHAQS

Conjugate

Alternative Names

STAT5B; signal transducer and activator of transcription 5B; STAT5; transcription factor STAT5B;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

Pathway

AGE/RAGE pathway; Acute myeloid leukemia; Angiopoietin receptor Tie2-mediated signaling; CXCR4-mediated signaling events