The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008]
Function
protein binding;
Synonyms
STAM2; signal transducing adaptor molecule (SH3 domain and ITAM motif) 2; signal transducing adapter molecule 2; Hbp; HSE1 homolog (S. cerevisiae); STAM-2; HSE1 homolog; Hrs-binding protein; STAM-like protein containing SH3 and ITAM domains 2; STAM2A; STAM2B; DKFZp564C047;
Citations
Publication ()
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