Anti-STAM2 monoclonal antibody, clone FQS9799

Antibody Isotype

IgG

Clone

FQS9799

Species Reactivity

Human

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive)

Conjugate

Application Notes

WB: 1/10000 - 1/50000; IHC-P: 1/50 - 1/100; ICC/IF: 1/100 - 1/250; Flow Cyt: 1/1000 - 1/10000;

Alternative Names

STAM2; signal transducing adaptor molecule (SH3 domain and ITAM motif) 2; signal transducing adapter molecule 2; Hbp; HSE1 homolog (S. cerevisiae); STAM-2; HSE1 homolog; Hrs-binding protein; STAM-like protein containing SH3 and ITAM domains 2; STAM2A; STA

Entrez Gene ID

UniProt ID

Antigen Description

Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

Pathway

Disease, organism-specific biosystem; EGFR downregulation, organism-specific biosystem; ESCRT-0 complex, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Endosomal Sorting Complex Required For Transport (ESCRT), organism-specific biosystem; IL-2 Signaling Pathway, organism-specific biosystem;