Anti-SPSB2 monoclonal antibody (DMABT-H13868)

Mouse anti-Human SPSB2 monoclonal antibody for WB, IHC, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
2F7
Species Reactivity
Human
Immunogen
GRCC9 (AAH02983,2a.a. ~00a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
SPSB2; splA/ryanodine receptor domain and SOCS box containing 2; SPRY domain-containing SOCS box protein 2; GRCC9; SSB 2; gene-rich cluster protein C9
Entrez Gene ID
UniProt ID

Product Background


Gene summary
SPSB2 (SplA/Ryanodine Receptor Domain And SOCS Box Containing 2) is a Protein Coding gene. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. An important paralog of this gene is SPSB4. This gene encodes a member of a subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal suppressor of cytokine signaling (SOCS) box. This protein plays a role in cell signaling. This gene is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. Alternative splicing results in multiple transcript variants.
Antigen Description
Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The function about SPSB2 antigen include molecular_function; protein binding.
Pathway
Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination andProteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing andpresentation, organism-specific biosystem; Immune System, organism-specific biosystem.

Citations


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References


Kuang, ZH; Lewis, RS; et al. The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation. JOURNAL OF CELL BIOLOGY 190:129-141(2010).
Nishiya, T; Matsumoto, K; et al. Regulation of Inducible Nitric-oxide Synthase by the SPRY Domain- and SOCS Box-containing Proteins. JOURNAL OF BIOLOGICAL CHEMISTRY 286:9009-9019(2011).

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