Specifications
Immunogen
Full length protein, corresponding to amino acids 1-127 of Human SEMA4G.
Applications
Application Notes
WB: 1:500-1:1000
Target
Alternative Names
SEMA4G; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G; semaphorin-4G; FLJ20590; KIAA1619; sema domain immunoglobulin domain (Ig) transmembrane domain (TM) and short cytoplasmic domain (semaphorin) 4G; semaphorin 4G; Semaphorin 4G precursor;
Product Background
Antigen Description
Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene.
Pathway
Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem;
Citations
Publication ()
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