The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008]
Function
P-P-bond-hydrolysis-driven protein transmembrane transporter activity; ribosome binding;
Synonyms
SEC61A1; Sec61 alpha 1 subunit (S. cerevisiae); protein transport protein Sec61 subunit alpha isoform 1; Sec61 alpha-1; sec61 homolog; protein transport protein SEC61 alpha subunit; protein transport protein Sec61 subunit alpha; SEC61; HSEC61; SEC61A;
Citations
Publication ()
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