Human Soluble Lectin-like Oxidized LDL Receptor-1 (DAG275)

Human Soluble Lectin-like Oxidized LDL Receptor-1 (aa 58 - 273), recombinant protein from E. coli Datasheet

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Product Overview
SolubleLectin-like Oxidized LDL Receptor-1 (sLOX), Recombinant. Consists of a singlepolypeptide chain corresponding to extracellular domain (a.a. 58-273) of thewhole lectin-like oxidized lipoprotein receptor-1 (LOX-1) molecule withouttags.
Nature
Recombinant
Tag/Conjugate
Unconjugated
Format
Purified, Lyophilized
Concentration
Lot specific
Buffer
Lyophilizedfrom 50mM Tris-HCl, pH 7.6, 150mM Sodium chloride
Preservative
None
Storage
2-8°C short term, -20°C long term
Introduction
This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimers disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
Antigen Description
Receptorthat mediates the recognition, internalization and degradation of oxidativelymodified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDLis a marker of atherosclerosis that induces vascular endothelial cellactivation and dysfunction, resulting in pro-inflammatory responses,pro-oxidative conditions and apoptosis. Its association with oxLDL inducesthe activation of NF-kappa-B through an increased production of intracellularreactive oxygen and a variety of pro-atherogenic cellular responses includinga reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. Inaddition to binding oxLDL, it acts as a receptor for the HSP70 proteininvolved in antigen cross-presentation to naive T-cells in dendritic cells,thereby participating in cell-mediated antigen cross-presentation.
Keywords
OLR1; oxidized low density lipoprotein (lectin-like) receptor 1; LOX1; LOXIN; SLOX1; CLEC8A; SCARE1; oxidized low-density lipoprotein receptor 1; hLOX-1; ox LDL receptor 1; lectin-type oxidized LDL receptor 1; scavenger receptor class E, member 1; C-type

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