Product Overview
Blocking/Immunizing peptide for anti-Rassf1 (mouse) antibody
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011]
Function
identical protein binding; metal ion binding; protein N-terminus binding; protein binding;
Synonyms
RASSF1; Ras association (RalGDS/AF-6) domain family member 1; ras association domain-containing protein 1; 123F protein; protein 123F2; RASSF1A tumor suppressor; Ras association (RalGDS/AF-6) domain family 1; 123F2; RDA32; NORE2A; REH3P21; Rassf1A; Rassf1B; Rassf1C; AA536941; AU044980;
Citations
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Chiu, RWK; Chim, SSC; et al. Hypermethylation of RASSF1A in human and rhesus placentas. AMERICAN JOURNAL OF PATHOLOGY 170:941-950(2007).
Prando, ED; Cavalli, LR; et al. Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines. EPIGENETICS 6:1413-1424(2011).