Anti-RASSF1 monoclonal antibody, clone 0B6

Antibody Isotype

IgG1

Clone

0B6

Species Reactivity

Human

Immunogen

Full length recombinant Human RASSF1 produced in E.coli, (NP_009113).

Conjugate

Application Notes

WB: 1/500; ICC/IF: 1/100;

Alternative Names

RASSF1; Ras association (RalGDS/AF-6) domain family member 1; ras association domain-containing protein 1; 123F2; NORE2A; RDA32; REH3P21; WUGSC:H_LUCA12.5; tumor suppressor protein RDA32; cardiac-specific ras association domain family 1 protein; pancreas-

Entrez Gene ID

UniProt ID

Antigen Description

Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK4 during Fas-induced apoptosis. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.

Pathway

Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; Non-small cell lung cancer, organism-specific biosystem; Non-small cell lung cancer, conserved biosystem; Pathways in cancer, organism-specific biosystem; p53 pathway, organism-specific biosystem;