Human RNF40 peptide

Specificity

Ubiquitously expressed. Expressed at higher level in testis, heart and pancreas, while it is only weakly expressed in lung, skeletal muscle and small intestine.

Nature

Synthetic

Tag/Conjugate

Unconjugated

SequenceSimilarities

Belongs to the BRE1 family.Contains 1 RING-type zinc finger.

Format

Liquid

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Entrez Gene ID

Antigen Description

The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Function

protein binding; protein complex binding; protein homodimerization activity; syntaxin-1 binding; ubiquitin protein ligase binding; contributes_to ubiquitin-protein ligase activity; zinc ion binding;

Synonyms

RNF40; ring finger protein 40, E3 ubiquitin protein ligase; BRE1B; RBP95; STARING; E3 ubiquitin-protein ligase BRE1B; BRE1-B; Rb-associated protein; BRE1 E3 ubiquitin ligase homolog B; 95 kDa retinoblastoma-associated protein; 95 kDa retinoblastoma protein binding protein;